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Inhibitor of DNA-binding protein : ウィキペディア英語版 | Inhibitor of DNA-binding protein Inhibitor of DNA-binding/differentiation proteins, also known as Id proteins comprise a family of proteins that heterodimerize with basic helix-loop-helix (bHLH) transcription factors to inhibit DNA binding of bHLH proteins. Id proteins also contain the HLH-dimerization domain but lack the basic DNA-binding domain and thus negatively regulate bHLH transcription factors when they heterodimermize with bHLH proteins. == Function == ID proteins are key regulators of development where they function to prevent premature differentiation of stem cells. In contrast, inappropriate regulation of ID proteins in differentiated cells can contribute to tumorigenesis. Finally expression of ID proteins in neurons halts neuron axon growth and allows elongation of neurons.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Inhibitor of DNA-binding protein」の詳細全文を読む
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